MEDICINAL PREPARATION TO PREVENT TRANSPLANT DETACHMENT, MONOCLONAL ANTIBODY TO CD3 ANTIGEN OF HUMAN T-LYMPHOCYTES, HYBRIDOME AND METHOD TO TREAT PATIENTS SUFFERING ACUTE TRANSPLANT DETACHMENT REACTION FOLLOWING KIDNEY TRANSPLANTATION Russian patent published in 2002 - IPC

FIELD: medicine, transplantology. SUBSTANCE: the preparation in question represents a solution of purified immunoglobulin IgG2a in physiological solution of phosphate-saline buffer, pH=7.2-7.4, at active substance content being 1-10 mg/ml and 0.01-0.02% TWIN-80. The method to treat patients suffering acute transplant detachment reaction following kidney transplantation is carried out by applying the suggested medicinal preparation which is injected at the amount of 1-5 mg for 7-14 d. Monoclonal antibody to CD3 antigen of human T-lymphocytes ICO-90 produced by the strain of hybridomal cultivated animal cells Mus.musculus L., ICO-90; N VSKK(P)368D which is bound human peripheral blood T- lymphocytes and thymocytes and, also, human T- lymphocytes' culture cells and those of Jurkat line and is not bound human peripheral blood leucocytes, erythrocytes, blood platelets and B- lymphocytes' culture cells, pre-B-lymphocytes, erythroblasts, myelocytes and monoblasts. EFFECT: decreased cases of transplant detachment and body allergization in patients following kidney transplantation. 11 cl, 7 ex, 2 tbl