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2 455 360

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IPC

C12P21/08(2006-01-01)

C12N5/20(2006-01-01)

C07K16/18(2006-01-01)

C07K16/36(2006-01-01)

G01N33/577(2006-01-01)

G01N33/543(2006-01-01)

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Application

2011105309/10, 2011-02-15

(24)

Start date

2011-02-15

(22)

Actual filing date

2011-02-15

(45)

Published

2012-07-10

(72)

Inventor

Kovnir Sergej VladimirovichOrlova Nadezhda AleksandrovnaVorob'Ev Ivan Ivanovich

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennost'Ju Tsentr Tekhnologii I Materialy" Novtekhmat")

CULTIVATED HYBRID CELL STRAIN OF MOUSE Sp2/0Ag14-SpBcG/APC-15/A3 - PRODUCER OF MONOCLONAL ANTIBODIES SPECIFIC TO HUMAN PROTEIN C, MONOCLONAL ANTIBODY SPECIFIC TO HUMAN PROTEIN C AND IMMUNOSORBENT FOR HUMAN PROTEIN C SORPTION CONTAINING MONOCLONAL ANTIBODY Russian patent published in 2012 - IPC C12P21/08 C12N5/20 C07K16/18 C07K16/36 G01N33/577 G01N33/543

Abstract RU 2455360 C1

FIELD: medicine.

SUBSTANCE: what is described is a hybrid cultured cell strain of the animals Mus museums Sp2/0Ag14-SpBcG/APC-15/A3 that is a produced of a monoclonal antibody specific to human protein C (to hPROC). The strain is deposited in the Russian Collection of Vertebrata Cell Culture of the Institute of Cytology of the Russian Academy of Sciences, No. 733(D). What is described is a monoclonal antibody prepared of the strain, specific to hPROC and showing the conformational properties. It binds hPROC in the presence of calcium ions and does not bind it in the presence of chelating agents. What is presented is an immunosorbent on the basis of said antibody.

EFFECT: applicability of the strain for preparing the MCA to hPROC, and producing on its basis an immune-affine sorbent for hPROC purification and concentration.

3 cl, 2 dwg, 3 tbl, 5 ex

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RU 2 455 360 C1

Authors

Kovnir Sergej Vladimirovich

Orlova Nadezhda Aleksandrovna

Vorob'Ev Ivan Ivanovich

Dates

2012-07-10—Published

2011-02-15—Filed