METHOD FOR DIAGNOSING DEVELOPING PLACENTAL INSUFFICIENCY AT EARLY STAGE Russian patent published in 2002 - IPC

FIELD: medicine. SUBSTANCE: method involves making biochemical analysis of blood to determine malonic dialdehyde (MDA) concentration, general blood plasma antioxidation activity (AOA) and evaluating organism antioxidation protection (OAP). Venous blood sample is taken once from pregnant woman in the period from the sixth to the twelfth week of pregnancy period. The analysis results are used for additionally determining catalase activity and lipid hydroxides concentration and evaluating organism antioxidation protection using depression coefficient of antioxidation potential K(K_DAC), calculating from formula
where AomAOA

, AomCAT, ComHP, ComMDA- are general antioxidation activity, catalase activity, lipid hydroxides concentration and malonic dialdehyde concentration determined from woman patient under study to normal state reference mean statistic values determined on healthy women during the first pregnancy trimester, respectively. Developing placental insufficiency diagnosis is set when K_DAC ≤ 0,75. EFFECT: enhanced effectiveness and reliability of diagnosis method.