METHODS OF SYNTHESIS OF 2-PHENYL-3-AMINOPYRIDINE OR ITS ACYLATED DERIVATIVE OR THEIR SUBSTITUTED PHENYL DERIVATIVES Russian patent published in 2002 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method of synthesis of 2-phenyl-3-amino-pyridine or its substituted phenyl derivatives. Method involves interaction of compound of the formula (VIII) with compound of the formula (IV) where substituents have the following values: X is Cl, Br or J; Z is H, (C₁-C₄)-alkyl, methoxy-group, trifluoromethoxy-group, F or Cl; Ar means (C₆-C₁₀)-aryl; R³ and R⁴ are taken among H₄(C₁-C₆)-alkyl. Process is carried out in inert solvent in the presence of base and palladium catalyst to yield compound of the formula (X) . Invention relates to also method of synthesis of acylated 2-phenyl-3-aminopyridine that involves interaction of compound of the formula (III) with compound of the formula (IV) in inert solvent in the presence of base and palladium catalyst to yield compound of the formula (V) that can be converted to compound of the formula (X). Synthesized compounds are antagonists of substance P and can be used in medicine. EFFECT: improved methods of synthesis, valuable medicinal properties. 15 cl, 5 ex