BENZOPYRANE AND BENZOCONDENSED COMPOUNDS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND A METHOD OF INHIBITION Russian patent published in 1999 - IPC

FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to benzopyrane and benzocondensed compounds of the formula (I) and its pharmaceutically acceptable salts where A' is O or CH₂; R³, R⁴ - H or hydroxy-group; R⁵ is -(CH₂)_nCHX⁹X¹⁰, -(CH₂)_nX¹⁰, -CH(OH)X¹⁰; n = 0 or 1; X⁹ - H or phenyl; X¹⁰ - H, alkyl, phenyl possibly substituted with R⁶ and R⁷ each of the latter - H or alkyl; R¹ is cis- or trans-(CH₂)_m-CX³X⁴X⁵ and substituted six-membered aromatic ring where m = 0 and X³ and X⁴ taken together with carbon atom to which they are bound form C_4-7-cycloalkyl; X⁵ - carboxy-group; R² - H. Synthesized compounds are antagonists of leukotriene B₄. EFFECT: improved method of synthesis and inhibition. 13 cl, 1 tbl, 16 ex