FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to a novel crystalline (-)-3R, 4R-trans-7-methoxy-2,2-dimethyl-3- phenyl-4-4-[2-(pyrrolidin-1- yl)ethoxy] phenylchroman hydrofumarate, method of its synthesis, pharmaceutical composition based on thereof and method of decrease or prophylaxis of bone resorption including administration to patient the effective amount of indicated novel compound. Invention can be used in medicine as a therapeutic agent. EFFECT: new compound indicated above, valuable medicinal property. 9 cl, 1 tbl
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