FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to novel pseudopolymorphic forms of 2-[2[4-[bis-(4-fluorophenyl)- methyl]-1-piperazinyl] -ethoxy] -acetic acid dihydrochloride, namely, to 2-[2-[4-[bis-(4-fluorophenyl)-methyl] -1-piperazinyl] - ethoxy]-acetic acid anhydrous dihydrochloride and 2-[2-[4-[bis- (4-fluorophenyl)-methyl[-1-piperazinyl]-ethoxy] -acetic acid dihydrochloride monohydrate. Invention relates to also methods of synthesis of these pseudopolymorphic forms and pharmaceutical compositions containing thereof. Compounds show excellent antihistaminic properties and useful as an antiallergic and antispasmodic agent. EFFECT: new compounds with valuable medicinal properties. 12 cl, 2 tbl, 5 ex
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Year |
Author |
Number |
| PHARMACEUTICAL COMPOSITION FOR ORAL INTAKE |
1998 |
- Fehnara Domeniko
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|
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2000 |
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1994 |
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| TABLET CONTAINING CETIRIZINE AND PSEUDOEPHEDRINE |
2002 |
- Fanara Domeniko
- Gisho Antoni
- Bervae Monik
- Deleer Mishel'
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| DERIVATIVE OF 2-(3H)-OXAZOLONE, METHODS OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF INHIBITION OF COX-2 ACTIVITY |
1997 |
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2000 |
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- Nad' Kal'Man
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- Tslementish D'Erd'
- Tempe Peter
- Vago Pal
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| (4-AMINO-2,6-DIMETHYLPHENYL SULFONYL)NITROMETHANE PHENYL ACETYL DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF |
1991 |
- Dehvid Robert Brittejn[Gb]
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2008 |
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|
SU1838306A3 |
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2015 |
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|
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