ENANTIOMERS OF 1-[(4-CHLOROPHENYL)PHENYLMETHYL]-4-[(4-METHYLPHENYL)SULFONYL]- -PIPERAZINE, METHOD OF THEIR SYNTHESIS, METHOD OF SYNTHESIS OF ENANTIOMERS OF 1-[(4-CHLOROPHENYL)PHENYLMETHYL]-PIPERAZINE, ENANTIOMERS OF 1-[(4-CHLOROPHENYL)PHENYLMETHYL]-PIPERAZINE, ENANTIOMERS OF 1-[(4-CHLOROPHENYL)PHENYLMETHYL]-PIPERAZINE DERIVATIVES Russian patent published in 1998 - IPC

Abstract RU 2118320 C1

FIELD: chemistry of heterocyclic compounds. SUBSTANCE: invention describes levo- and dextrorotatory enantiomers of 1-[(4-chlorophenyl)phenylmethyl] -4-[(4-methyl- -phenyl)sulfonyl]-piperazine of the formula (I): , method of their synthesis and using for synthesis of optically pure enantiomers of 1-[(4-chlorophenyl)phenylmethyl] -piperazine which are valuable intermediate compounds that can be used for synthesis of therapeutically and optically active antihistaminic compounds of the general formula (V): where R - methyl, (3-methylphenyl)-methyl, (4-tert.-butylphenyl)-methyl, 2-(2-hydroxyethoxy)-ethyl, 2-[(2-hydroxyethoxy)ethoxy]-ethyl, 2-(carbamoylmethoxy)-ethyl, 2-(methoxycarbonylmethoxy)-ethyl, 2-(carboxymethoxy)-ethyl of very high optical purity. Synthesized compounds can be used in medicine. EFFECT: improved method of synthesis. 8 cl, 15 ex, 6 tbl

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RU 2 118 320 C1

Authors

Ehrik Kosseman

Gi Bodson

Zhan Gober

Dates

1998-08-27Published

1994-03-14Filed