FIELD: chemistry of heterocyclic compounds. SUBSTANCE: invention describes levo- and dextrorotatory enantiomers of 1-[(4-chlorophenyl)phenylmethyl] -4-[(4-methyl- -phenyl)sulfonyl]-piperazine of the formula (I): 
, method of their synthesis and using for synthesis of optically pure enantiomers of 1-[(4-chlorophenyl)phenylmethyl] -piperazine which are valuable intermediate compounds that can be used for synthesis of therapeutically and optically active antihistaminic compounds of the general formula (V): 
where R - methyl, (3-methylphenyl)-methyl, (4-tert.-butylphenyl)-methyl, 2-(2-hydroxyethoxy)-ethyl, 2-[(2-hydroxyethoxy)ethoxy]-ethyl, 2-(carbamoylmethoxy)-ethyl, 2-(methoxycarbonylmethoxy)-ethyl, 2-(carboxymethoxy)-ethyl of very high optical purity. Synthesized compounds can be used in medicine. EFFECT: improved method of synthesis. 8 cl, 15 ex, 6 tbl
| Title |
Year |
Author |
Number |
| METHOD OF SYNTHESIS OF 2-[2[4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINYL]ETHOXY]-A- CETIC ACID OR ITS DICHLOROHYDRATE |
0 |
- Gi Bodzon
- Erik Kossman
- Zhan Gober
|
SU1838306A3 |
| 1,4-SUBSTITUTED PIPERAZINES OR 4-ALKYLIDENYL PIPERIDINES, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT |
2000 |
- Skehnnehll Ral'F
- Shatelehn P'Err
- Toj-Pehlmer Ehnna
- Differdehng Ehdmond
- Ehllis Dzhejms
- Ljassua Mari-Agnes
- Jung Mishell
- Kej Ksiong
- Khussoin Sadzhdzhat
- Greval Gurmit
- L'Juis Timoti
|
RU2241707C2 |
| 2-/4-(DIPHENYLMETHYL)-1-PIPERAZINYL/-ACETIC ACIDS OR THEIR AMIDES,OR THEIR NONTOXIC PHARMACEUTICALLY ACCEPTABLE SALTS SHOWING SPASMOLYTIC AND ANTIHISTAMINIC ACTIVITY |
0 |
- Ezhen Baltes
- Zhan De Lannoi
- Lyudovik Rodrigez
|
SU1310397A1 |
| SUBSTITUTED 4-(1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL)-1H-IMIDAZOLES AND 4-(2,3-DIHYDRO-1H-INDENE-1-YL)-1H-IMIDAZOLES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1995 |
- Zhan-P'Er Zheer
- Zhenev'Ev Mot
- Ehdmon Differding
- Zhan-P'Er Ehnishar
|
RU2156239C2 |
| (-)-ENANTIOMER OF 2-[2-(1-CHLOROCYCLOPROPYL)-3-(2-CHLOROPHENYL)-2-HYDROXYPROPYL]-2,4-DIHYDRO -[1,2,4]-TRIZOLE-3-THIONE AND METHOD FOR ITS PREPARING |
2000 |
- Grosser Rolf
- Jautelat Manfred
- Mauler-Makhnik Astrid
- Duttsmann Shtefan
- Khehnssler Gerd
- Shtentsel' Klaus
|
RU2238270C2 |
| PSEUDOPOLYMORPHIC FORMS OF 2-[2-[4-[BIS-(4- FLUOROPHENYL)-METHYL]-1-PIPERAZINYL]-ETHOXY]- ACETIC ACID DIHYDROCHLORIDE |
1998 |
- Bervaer Monik
- Bodson Gi
- Delirs Mishel'
- Dozhimon Sharl'
- Fanara Domeniko
- Timmerman Zhak
|
RU2182575C2 |
| 2-OXO-1-PYRROLIDINE DERIVATIVES, METHOD OF OBTAINMENT |
2001 |
- Sartis Dzhon
- Marmon Violeta
- Differdehn Ehdmon
- Zimmermann Vinsent
|
RU2355680C2 |
| PHARMACEUTICAL COMPOSITION FOR ORAL INTAKE |
1998 |
- Fehnara Domeniko
- Bervaer Monik
- Nol'F Filipp
- Vrehnk Anri
- Delirs Mishel'
|
RU2192863C2 |
| METHOD OF SYNTHESIS OF 1-[[[5-(4-CHLOROPHENYL)-2-FURANYL]METHYLENE]AMINO]- 3-[4-(4-METHYL-1-PIPERAZINYL)BUTYL]-2,4-IMIDAZOLIDINEDIONE DIHYDROCHLORIDE |
1999 |
- Mehtson Patritsija Ehnn
- Godlevski Majkl Selden
- Korroz Daniehl
- Guggisberg Iv
|
RU2194706C2 |
| DEXTROROTATORY ISOMER OF 6-(5-CHLORO-2-PYRIDYL)-(4-METHYL-1- -PIPERAZINYL)-5-CARBONYLOXY-7-OXO-6,7-DIHYDRO-5H-PYRROLO- -[3,4-B]-PYRAZINE AND ITS PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALT, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1992 |
- Klod Kotrel'[Fr]
- Zherar Russel'[Fr]
|
RU2110519C1 |
