FIELD: medicine.
SUBSTANCE: invention refers to various crystalline forms of (E)-N-{4-[3-chlor-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide maleate salts, (NERATINIB), methods for preparing them, as well as to a pharmaceutical composition for kinase activity inhibition HER-2 containing them, and a method for preventing, treating or inhibiting cancer.
EFFECT: there are prepared new forms of maleate salts effective in treating cancer diseases, particularly under the influence of kinases of the family of epidermal growth factor receptors.
22 cl, 2 ex, 11 tbl, 8 dwg
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|
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