STEROID COMPOUNDS, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION, METHODS FOR REGULATION AND IMPROVING FOR REPRODUCTION, INTERMEDIATE COMPOUNDS Russian patent published in 2006 - IPC C07J41/00 C07J43/00 A61K31/58 A61P15/08 

FIELD: organic chemistry, steroids, biology.

SUBSTANCE: invention relates to steroid compounds of the general formula (X):

wherein in fragment of the formula XA:

each bond between C⁶ and C⁷, between C⁷ and C⁸, between C⁸ and C⁹, between C⁸ and C¹⁴ and between C¹⁴ and C¹⁵ is a single or double bond under condition that each atom C⁶, C⁷, C⁸, C⁹, C¹⁴ and C¹⁵ is bound with adjacent C-atom by a single bond or one double bond; CR³ means -CHOH; A means methylene or ethylene group; R⁴ and R^4' mean (C₁-C₄)-alkyl, hydrogen atom (H); R²⁰ means (C₁-C₄)-alkyl; R²³ and R^23' mean in common piperidine-1-yl, morpholine-4-yl, pyrrolidine-1-yl, piperazinyl possibly substituted with -OH, benzene, pyridine, pyrimidine, phenyl, alkoxycarbonyl group, or R²³ means H and R^23' means substituted alkyl. These compounds can be used for stimulation of meiosis in human oocytes. In proposed compounds steroid differs specifically as nitrogen atom of amino-group is bound with C¹⁷-atom of steroid skeleton by spacer A.

EFFECT: improved methods of synthesis, valuable biological properties of compounds.

16 cl, 8 dwg, 2 tbl, 30 ex