FIELD: chemistry.
SUBSTANCE: group of inventions relates to use of sigma-receptor ligand, which is 4-{2-[5-methyl-1-(naphthalene-2-yl)-1H-pyrazole-3-yloxy]ethyl}morpholine or its salt for prevention and/or treatment of induced opioids hyperalgesia (OIH) associated with opioid therapy; use of its combination with opioid or opiatnym joint along same purpose; to use thereof for preparing drug for preventing and/or treating OIH associated with opioid therapy; to method of corresponding treatment.
EFFECT: technical result consists in prevention of OIH developing while maintaining dose of opioid.
8 cl, 16 dwg, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| SIGMA LIGANDS FOR POTENTIATING ANALGESIC EFFECT OF OPIOIDS AND OPIATES IN POSTOPERATIVE PAIN AND ATTENUATING DEPENDENCY THEREOF | 2011 |
|
RU2563460C2 |
| USE OF SIGMA LIGANDS FROM PAIN IN BONE CANCER | 2011 |
|
RU2585095C2 |
| SIGMA-LIGANDS FOR APPLICATION IN PREVENTION AND/OR TREATMENT OF POSTOPERATIVE PAIN | 2011 |
|
RU2569055C2 |
| USE OF SIGMA LIGANDS IN DIABETES TYPE-2 ASSOCIATED PAIN | 2012 |
|
RU2608943C2 |
| 1-ARYL-3-AMINOALKOXYPYRAZOL AS SIGMA LIGANDS INTENSIFYING ANALGESIC ACTION OF OPIOIDS AND RELIEVING ADDICTION THERETO | 2009 |
|
RU2519060C2 |
| SIGMA-RECEPTOR INHIBITORS | 2005 |
|
RU2417987C2 |
| SIGMA-RECEPTOR LIGANDS FOR PREVENTING OR TREATING PAIN CAUSED BY CHEMOTHERAPY | 2010 |
|
RU2543382C2 |
| PHARMACEUTICAL COMPOSITIONS CONTAINING SIGMA RECEPTOR LIGANDS | 2010 |
|
RU2549882C2 |
| PYRAZOLE COMPOUNDS AS SIGMA RECEPTOR INHIBITORS | 2011 |
|
RU2582338C2 |
| 1,2,4-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHBITORS | 2007 |
|
RU2451015C2 |
