NUCLEOSIDES WITH MODIFIED SUGARS AND OLIGONUCLEOTIDES Russian patent published in 2000 - IPC

Abstract RU 2145964 C1

FIELD: medicine. SUBSTANCE: described are new nucleosides with modified sugars of general formula I wherein R11

,R₁-R₅,R15

,R13

,X,B are as defined in claim 1. Said oligonucleotides with sugar constituent are used as antisense therapeutic agents since they have improved resistance to nucleases and to absorption by cells and retain specificity and affinity to sequence of nucleic acid targets in vitro or in vivo. Also described are oligonucleotides. EFFECT: improved properties of the nucleosides. 21, 63 ex, 14 dwg

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RU 2 145 964 C1

Authors

Vong Guondzhi

Ramasami Kandasami

Sajfert Uilfrid

Dates

2000-02-27—Published

1995-11-02—Filed