FIELD: medicine.
SUBSTANCE: invention relates to medicine, in particular, to a pro-liposomal pharmaceutical depot formulation, a method for preparing same, a pro-liposomal non-aqueous base formulation, a method for preparing same, and a kit for administering a hydrophobic active pharmaceutical ingredient. According to the present invention, disclosed are pro-liposomal non-aqueous pharmaceutical depot formulations, containing natural non-synthetic lecithin-based phospholipid, oil as a non-aqueous pharmaceutically acceptable carrier, ethanol as viscosity regulator.
EFFECT: implementation of the invention allows to obtain a pro-liposomal non-aqueous depot formulation, ensuring the maintenance of therapeutically effective levels of API for several days, wherein the pro-liposomal depot formulation is a stable, transparent oily solution, characterised by low viscosity.
53 cl, 4 dwg, 17 tbl, 17 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DEPOT FORMULATIONS OF LOCAL ANESTHETIC AND METHODS FOR PREPARATION THEREOF | 2013 |
|
RU2664700C2 |
| MIXTURES AND COMPOSITIONS CONTAINING ALKYLAMMONIUM EDTA SALT | 2017 |
|
RU2775780C2 |
| NOVEL DEPOT-PREPARATIONS FOR INJECTION | 2003 |
|
RU2310450C2 |
| ANESTHETIC COMPOSITIONS WITH DELAYED RELEASE AND METHODS FOR THEIR PREPARATION | 2018 |
|
RU2791481C2 |
| SUSTAINED RELEASE ANESTHETIC COMPOSITIONS AND METHODS FOR PREPARATION THEREOF | 2019 |
|
RU2820649C2 |
| DIRECTED DELIVERY OF SPRAY-DRIED COMPOSITIONS INTO THE LUNGS | 2016 |
|
RU2731212C2 |
| PROSTACYCLIN ANALOGUE PREPARATIONS | 2017 |
|
RU2757903C2 |
| DEAMORPHIZATION OF SPRAY-DRIED FORMULATIONS VIA SPRAY-BLENDING | 2014 |
|
RU2698331C2 |
| PHARMACEUTICAL COMPOSITIONS FOR USE IN TREATMENT OF PAIN | 2020 |
|
RU2812902C2 |
| PHOSPHOLIPID DEPOT PREPARATION | 2010 |
|
RU2595865C2 |
