FIELD: organic chemistry, biochemistry, amino acids, pharmacy. SUBSTANCE: invention describes new derivatives of glutamic acid of the formula (I) where A means sulfur atom; X means CH2; Y means sulfur atom; B means hydrogen atom; C means hydrogen atom; R1 and R2 each independently means hydrogen atom or lower alkyl that inhibit activity of enzyme glycineamideribonucleotide formyltransferase. Invention describes intermediate compounds used for synthesis of compounds of the formula (I), pharmaceutical compositions containing compounds of the formula (I), their use for inhibition of activity of glycineamideribonucleotide formyl-transferase and their use for inhibition of the growth and proliferation of cells of higher organism or microorganisms, for example, bacteria, yeast and fungi. Indicated compounds show antitumor, anti-inflammatory, antipsoriatic and/or immunosuppressive activities. Invention relates also to a method of synthesis of compounds of the formula (I). EFFECT: new derivatives of glutamic acid indicated above, valuable pharmacological properties. 32 cl, 5 tbl, 2 ex
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