FIELD: organic chemistry, biochemistry, enzymes. SUBSTANCE: invention relates to compounds of the formula (I) 
where radical values are determined in the description, their prodrugs and their pharmaceutically acceptable salts. Compounds show the high anticoagulating activity and can be used in treatment and prophylaxis of diseases associated with thrombin. Invention describes also a pharmaceutical composition comprising a compound by claim 1. EFFECT: valuable biochemical and medicinal properties of compounds. 11 cl, 2 tbl, 12 ex
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