DERIVATIVES OF IMIDAZO-[1,5-A]-PYRIDINE AS INHIBITORS OF SERINE PROTEASES AND PHARMACEUTICAL COMPOSITION Russian patent published in 2001 - IPC

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to inhibitor of serine proteases which is a derivative of imidazo-[1,5-a] -pyridine containing structural unit (link) of the general formula (I) where R₁ and R₂ mean hydrogen atom; R₃ and R₄ mean independently hydrogen atom, (1-6C)-alkyl or in common they form =CH-NR₅R₆ being R₅ and R₆ mean (1-6C)-alkyl; X means hydrogen atom, R₇, acetyl, Ртс, R₇ = SO₂, N-protective group where R₇ means (1-12C)-alkyl or (1-14C)-aryl; P₃ means a bond, D-Tig, Atc, D-amino acid with hydrophobic side chain; P₂ means Pro, Gly, Val, Jle, 2,4-Me-P₂0, 3,3-Dmp, Jlc, Thr, Hyp, 2,2-Dmt or 5,5-Dmt; or P₂ means a bond when P₃ means a bond also and X means R₇-SO₂-; or P₂ and P₃ in common mean the structure that is similar to dipeptide of the formula (II) which in positions labeled by asterisks can be condensed with benzene ring and where R₉ is hydrogen atom; or its pharmaceutically acceptable salt. Invention describes a pharmaceutical composition also. EFFECT: valuable biochemical properties of compounds. 5 cl