6,9-DISUBSTITUTED 2-[TRANS-(4-AMINOCYCLOHEXYL)-AMINO]PURINES Russian patent published in 2002 - IPC

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: invention relates to novel compounds of the general formula (I) where R is taken among group comprising of R2, R2NH- or H₂N-R3- where R2 is taken among group comprising of C₁-C₈-alkyl and compound of the formula (II) where Z is taken among group consisting of phenyl, heterocycle and cycloalkyl; each R4 means independently hydrogen atom or C₁-C₄-alkyl and n is whole number = 1-8; where each C₁-C₈-alkyl and z are substituted optionally with 1-3 substitutes that can be similar or different and taken among group consisting of Hal, OH and C₁-C₄-alkyl; R3 means C₁-C₈-alkylene; and R1 is taken among group consisting of cyclopentyl and isopropyl. Invention relates to their pharmaceutically acceptable salts, optical isomers and hydrates also. Except for, invention presents method of inhibition of cellular cycle development, method of inhibition of cycline-dependent kinase activity, especially, cdk-2, method of prophylaxis of apoptosis in neuron cells and method of inhibition of blastomas development and composition comprising effective amount of compound of the formula (I) and pharmaceutical composition comprising effective inhibitory amount of compound of the formula (I) in mixture with or another combination with one or some pharmaceutically acceptable carriers or excipients. EFFECT: valuable medicinal and biochemical properties of compounds. 34 cl, 2 tbl, 62 ex