1,3,4-OXADIAZOL-2-ONES AS PPAR-DELTA MODULATORS AND APPLICATION THEREOF Russian patent published in 2009 - IPC C07D417/12 C07D413/12 A61K31/4245 A61K31/425 A61P3/10 A61P3/06 

FIELD: medicine.

SUBSTANCE: there are described derivatives of 1,3,4-oxadiazol-2-one of formula I and their pharmaceutically acceptable salts wherein ARYL represents phenyl which can have one substitute chosen from halogen; W represents chain or (CH₂)m where m designates an integer 1 to 4; Z represents -O(CH₂)n-, -(CH₂)n-Y-(CH₂)n- where Y designates O, n independently means an integer 1 to 5; X represents O or S; R₁ represents C_1-6 alkyl; R₂ represents substituted phenyl where substitutes are chosen from the group including C_1-6alkyl, C_1-4perfluoralkyl. There are also described pharmaceutical composition, and method of treating a disease in mammal wherein said disease can be modulated by PPAR-delta receptor binding activity.

EFFECT: compounds possess agonist or antagonist activity with respect to PPAR-delta receptor.

9 cl, 2 tbl, 34 ex