FIELD: chemistry.
SUBSTANCE: described are derivatives of 1,3,4-oxadiazol-2-on of formula (I) 
, where ARYL represents phenyl; Z represents -O(CH2)n- and n represents independent integer number from 1 to 5; X represents S; R1 represents C1-6alkyl; R2 represents phenyl, substituted with C1-6perfluoralkyl; or its pharmaceutically acceptable salt; based on it pharmaceutical composition; and method of disease treatment, where disease can be modulated by activity of PPAR-delta binding.
EFFECT: obtaining compounds which possess agonistic or antagonistic activity.
7 cl, 5 ex
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