NOVEL CYCLIN-DEPENDENT KINASE CDK9 INHIBITOR Russian patent published in 2020 - IPC C07D417/04 C07D417/14 A61K31/427 A61P35/00

Abstract RU 2738654 C1

FIELD: chemistry; pharmaceutics.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, where Y is selected from a group consisting of p-fluorobenzoyl, trans-4-aminocyclohexyl, in which N is optionally substituted with R₃, and trans-4-aminocyclohexylmethyl; Z is selected from a group consisting of NH, S and O; R₁ is selected from a group consisting of hydrogen and halogen; R₂ is selected from a group consisting of hydrogen, C3-C6 cycloalkyl, 4-tetrahydropyranyl, optionally substituted with R₄, and phenyl, optionally substituted with R₄; R₃ is selected from a group consisting of C2-C6 alkanoyl and C1-C3 alkoxy (C1-C3) alkyl; R₄ is selected from a group consisting of cyano and halogen. Invention also relates to a pharmaceutical composition for inhibiting cyclin-dependent kinase CDK9 based on said compound.

EFFECT: technical result is obtaining novel compounds and a pharmaceutical composition based thereon, which can be used in medicine for treating cancer diseases.

14 cl, 5 tbl, 14 dwg, 24 ex

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RU 2 738 654 C1

Authors

Chzhou, Gan

Dates

2020-12-15—Published

2018-01-03—Filed