DERIVATIVES OF ISOXAZOLE AND CROTONIC ACID AMIDE Russian patent published in 2002 - IPC

FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to novel derivatives of isoxazole and crotonic acid amide of the general formula (I) where R¹ means residue of the formula (II) or (III) ; R² means O-(CH₂)_n-CH=CH₂; n means a whole number 1-3, -O-(CH₂)_m-CH₂-halogen; m means a whole number 1-3; halogen means fluorine, chlorine, bromine or iodine atom, residue of the formula (V) where R³ means halogen or NH₂; R⁴ means hydrogen atom, and/or their physiologically acceptable salts. Invention relates also to derivatives of isoxazole and crotonic acid amide of the formula (IV) where R¹ means residue of the formula (II) or (III); L means bridge link of group (a): -O-(CH₂)_n-CH₂- where n means a whole number 1-3; (b): -NH-C(O)-CH(R⁴)(R³) where R³ means hydrogen atom; X means polymer or solid body. Compound of the formula (IV) can be used for detection of specifically bound proteins from cellular extracts, serum, blood or synovia, for protein purification, for modification of microtiter plates or for preparing chromatography material, especially affinity chromatography material. EFFECT: valuable properties of synthesized compounds. 7 cl, 3 tbl, 10 ex