DERIVATIVES OF PROPANOLAMINE, METHODS OF THEIR SYNTHESIS AND AGENT BASED ON THEREOF Russian patent published in 2003 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of propanolamine of the formula (I) and their pharmaceutically acceptable salts where R¹ and R² mean phenyl, naphthyl, pyridyl, thienyl, pyrimidinyl, thiazolyl, quinolyl, piperazinyl, oxazolyl that can be substituted with halogen atom, OH, NO₂,NH₂, COOH and others; R³-R⁸ mean hydrogen atom, hydroxyl, (C₁-C₈)-alkoxyl, NH₂,-NHR⁹,-N(R⁹)R¹⁰; R⁹-R¹⁰ mean hydrogen atom or (C₁-C₈)-alkyl; X means CH or N; Y means CH or N under condition that residues R¹,R², X and Y do not mean simultaneously: R¹ - phenyl; R² - phenyl; X CH; Y CH. Compounds of the formula (I) exhibit activity inhibiting uptake of [³H]-taurocholate and can be used in medicine. EFFECT: improved methods of synthesis, valuable medicinal properties of agent. 6 cl, 7 tbl