N-ARYLSULFONYL AMINO ACID OMEGA-AMIDES Russian patent published in 2004 - IPC

FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to N-arylsulfonyl amino acid omega-amides of the formula (I) and/or stereoisomeric forms of the compound (I) and/or physiologically acceptable salts of the compound (I) wherein R¹ means phenyl, phenyl once substituted with halogen atom, heterocycle residue taken among the following group: morpholine, pyrrolidine; R² means hydrogen atom; R³ means -alkyl-C(O)- wherein R⁶ and R⁷ in common with nitrogen atom to which they are bound form residue if the formula (IIA) and the formula (IIe) wherein q means 0 or 1; Z means carbon atom or covalent bond; R⁸ means hydrogen atom or halogen atom; or R³ means -alkyl-C(O)-Y wherein Y means residue of the formula (IIc) or (IId) wherein R⁸ means hydrogen atom of halogen atom; R⁹ means hydrogen atom; or R³ means -alkyl-C(O)- wherein R⁹ has above given values; o means a whole number 2; R⁴ and R⁵ in common with ring amino-group form 4-7-membered ring wherein one carbon atom is substituted for -O-; A means a covalent bond; B means wherein m means 0; X means CH= CH-. Compounds of the formula (I) are inhibitors of matrix metalloproteases and can be used in medicine. EFFECT: valuable biological and medicinal properties of compounds. 4 cl, 3 tbl, 16 ex