DERIVATIVES OF INDOLE OR BENZIMIDAZOLE FOR MODULATION OF IkB KINASE Russian patent published in 2008 - IPC C07D401/14 C07D403/12 C07D403/14 C07D413/14 C07D417/04 A61K31/506 A61P19/00 

FIELD: organic chemistry, medicine, biochemistry, pharmacy.

SUBSTANCE: invention relates to novel compounds of the formula (I): and/or stereomer form of compound of the formula (I), and/or physiologically compatible salt of compound of the formula (I) wherein X and M are similar or different and mean independently of one another nitrogen atom (N) or -CH; R1 and R11 are similar or different and mean independently of one another: (1.) hydrogen atom; (2.) fluorine (F), chlorine (Cl), iodine (J) or bromine (Br) atom; R2 means: (1.) heteroaryl residue of group comprising 1,3,4-oxadiazole, oxadiazolylidinedione, oxadiazolone, thiazole, and heteroaryl residue is unsubstituted or 1-3-times substituted independently of one another: (1.1.) keto-group; (2) -C(O)-R⁵ wherein R⁵ means hydrogen atom or -(C₁-C₄)-alkyl, or (3.) -C(O)-N(R⁷)-R⁸ wherein R⁷ and R⁸ mean independently of one another hydrogen atom, -(C₁-C₄)-alkyl-OH, -O-(C₁-C₄)-alkyl or -(C₁-C₄)-alkyl; R3 means hydrogen atom or -(C₁-C₄)-alkyl; R4 means: (1.) heteroaryl residue of group comprising thiazole, isothiazole, pyridine, pyrazine, pyrimidine wherein heteroaryl residue is unsubstituted or 1-3-times substituted independently of one another with -(C₁-C₅)-alkyl, halogen atom, trifluoromethyl, or (2.) aryl residue of group comprising phenyl. Also, invention relates to a method for preparing a medicinal agent and to using compounds based on the formula (I) possessing activity with respect to IkB kinase. Invention provides synthesis of novel compounds possessing useful biological properties.

EFFECT: valuable medicinal and biochemical properties of compounds and pharmaceutical agent.

6 cl, 67 ex