FIELD: microbiology. SUBSTANCE: invention relates to methods of protection of microorganisms from heat effect in bacterial preparations preparing. Method of protection of microorganisms from increased temperature involves addition of deuterium oxide to bacterial suspension being 5 min, not less, before effect by increased temperature and concentration of deuterium oxide in final product is 10-60%. Method ensures to enhance titer value of viable microorganisms on an average by 1.5-3-fold in biological preparation preparing after thermal effect. EFFECT: enhanced effectiveness of protection. 4 tbl
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