DERIVATIVES OF PYRIDO-1,2,4-THIADIAZINE OR PYRIDO-1,4-THIAZINE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF MANIFESTATION OF ACTIVITY INHIBITING INSULIN SECRETION Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes derivatives of pyrido-1,2,4-thiadiazine or pyrido-1,4-thiazine of the general formula (I): where B means >NR⁵ or >CR⁵R⁶ where R⁵ and R⁶ mean independently C_1-6--alkoxy-group or C_1-6--alkyl; D means -S(=O)₂-; R¹ means hydrogen atom and R⁴ means hydrogen atom; or R⁴ in common with R⁵ mean one of bonds in double bond between atoms 2 and 3 of the formula (I); or R¹ in common with R⁴ mean one of bonds in double bond between atoms 3 and 4 of the formula (I); R² means hydrogen atom; R³ means R¹¹, -NR¹¹R¹², arylalkyl where R¹¹ means hydrogen atom, unbranched or branched C_1-18-alkyl possibly mono- or poly-substituted with halogen atom, hydroxy-, C_1-6- alkoxy-group or aryl; R¹² means hydrogen atom; A in common with carbon 5 and 6 of thiazine forms pyridine ring taken among: where R⁷, R⁸, R⁹ mean independently hydrogen or halogen atom under condition that when B means NR⁵, D means SO₂ and R² means hydrogen atom then R³ can not mean hydrogen atom or unsubstituted C_1-6-alkyl. Invention describes also pharmaceutical composition showing activity inhibiting insulin secretion and method of manifestation of activity inhibiting insulin secretion. Invention provides synthesis of novel compounds showing useful biological properties. EFFECT: valuable medicinal properties of compounds. 17 cl, 1 tbl, 11 ex