DERIVATIVES OF BENZOPYRANE-2-ONE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION COMPRISING THEREOF AND INTERMEDIATE COMPOUNDS Russian patent published in 2002 - IPC

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to derivatives of benzopyrane-2-one of the formula (I) where R₁ means hydrogen atom, hydroxyl radical, optionally substituted alkyl radical optionally broken by oxygen, sulfur or nitrogen atom, alkoxyl radical or radical NR_cR_d; X means oxygen atom or radical N-N(CH₃)₂, or radical NOalc₂ where alc₂ means optionally substituted alkyl radical optionally broken by oxygen, sulfur or nitrogen atom; R₂ means hydrogen atom or halogen atom; R₃ means hydrogen atom, alkyl radical or halogen atom; R₄ means radical NR_gR_h , optionally substituted aryl or heteroaryl radical; R₅ means hydrogen atom or O-alkyl; R₆ means alkyl or CH₂-O-alkyl; R₇ means hydrogen atom or alkyl. Indicated compounds show antibacterial activity. Invention describes method of synthesis of compounds of the formula (I) and intermediate compounds of formulas (II) , (III) and (IV) used in its and pharmaceutical composition based on compounds of the formula (I). EFFECT: improved method of synthesis, valuable activity. 21 cl, 36 ex