IMIDAZOLIDINES SUBSTITUTED WITH HETEROCYCLE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to imidazolidines of the general formula (I) where H means saturated heterocyclic radical including 4-7 atoms and containing either oxygen, nitrogen atom or sulfur atom being nitrogen atom can be substituted with lower alkyl and sulfur atom can be oxidized; or two oxygen atoms being indicated heterocycle can be substituted with one or some lower alkyls; Ar is phenyl possibly substituted with two radicals taken among CF₃, CN, alkoxyl-group or alkylthionyl- -group; X is oxygen or sulfur atom; Y is oxygen atom or radical NH; R₃ is H, alkyl possibly substituted with halogen atom or hydroxyl-group, free or esterified carboxyl- or cyano-radical and their additive salts also showing antiandrogenic activity. EFFECT: improved method of synthesis, valuable antihormonal properties. 9 cl, 25 ex