FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of cycloalkanopyridine of the general formula (I)
where A means unsubstituted aryl with 6-10 carbon atoms or aryl substituted with phenyl, nitro-group, halogen atom, trifluoromethyl group or trifluoromethoxy-group or residue of the formula given in the invention claim; E means cycloalkyl with 3-8 carbon atoms, linear or branched alkyl with 1-8 carbon atoms or unsubstituted phenyl or phenyl substituted with halogen atom or trifluoromethyl group; R1 and R2 form in common linear or branched alkylene chain with 1-7 carbon atoms that is substituted with carbonyl group and/or residue of the formula given in the invention claim, mixture of their isomers or separate isomers, their salts and N- oxides with exception for 5(6H)-quinolone, 3-benzoyl-7,8-dihydro-2,7,7-trimethyl-4-phenyl. Also, invention discloses intermediate compounds used for synthesis of indicated derivatives of cycloalkanopyridine and pharmaceutical composition based on thereof. Invention can be used in medicine for treatment and prophylaxis of hypolipoproteinemia, dyslipidemia, hypertriglyceridemia, hyperlipidemia or arteriosclerosis. EFFECT: valuable medicinal properties of compounds. 6 cl, 5 tbl, 373 ex
Title |
Year |
Author |
Number |
DERIVATIVES OF 1,4-DIHYDROPYRIDINE, MIXTURES OF THEIR ISOMERS OR SEPARATE ISOMERS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND 2-CHLORO-3-CYANOBENZALDEHYDE |
1994 |
- Gejnrikh Mejer
- Vol'Fgang Khartvig
- Bodo Junge
- Rudol'F Shokhe-Loop
- Tsan Gao
- Bernkhard Shmidt
- Maarten De Jonge
- Tojnis Shuurman
|
RU2155751C2 |
DERIVATIVES OF CYCLOALKANOINDOLE AND AZAINDOLE, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, DERIVATIVES OF CARBOXYLIC ACID AS PARENT COMPOUNDS AND PHARMACEUTICAL COMPOSITION INHIBITING RELEASE OF LIPOPROTEINS ASSOCIATED WITH APOLIPOPROTEIN B-100 |
1995 |
- Ul'Rikh Mjuller
- Richard Konnell
- Zigfrid Gol'Dmann
- Rudi Grjuttsmann
- Martin Bojk
- Khil'Mar Bishoff
- Dirk Dentser
- Anke Domdej-Bette
- Shtefan Vol'Fejl'
|
RU2157803C2 |
ALKOXIMINOACETIC ACID AMIDES, FUNGICIDE AGENT BASED ON THEREOF AND METHOD OF CONTROL OF FUNGAL DISEASES IN PLANTS |
1996 |
- Tomas Zajtts
- Gerd Khehnssler
- Klaus Shtentsel'
|
RU2167853C2 |
1-ALKYL-3,5-DIALYL-1,4-DIHYDROPYRIDINE DERIVATIVES AS MIXTURE OF ISOMERS THEREOF |
1995 |
- Klaus Urbans
- Khans-Georg Khejne
- Tomas Glazer
- Rejlinde Vittka
- Zhan-Mari-Viktor De Vri
- Khenning Zommermejer
|
RU2158259C2 |
4H-PYRAN DERIVATIVES, MIXTURE OF ISOMERS THEREOF, INDIVIDUAL ISOMERS AND SALTS THEREOF |
1996 |
- Klaus Urbans
- Khans-Georg Khajne
- Bodo Junge
- Frank Mauler
- Tomas Glazer
- Rajlinde Vittka
- Zhan-Mari-Viktor De Vri
|
RU2164915C2 |
DERIVATIVES OF 4-ARYL-6-AMINONICOTINIC ACID AND THEIR SALTS |
1995 |
- Klaus Urbans
- Zigfrid Gol'Dmann
- Khans-Georg Khejne
- Bodo Junge
- Rudol'F Shokhe-Loop
- Khenning Zommermejer
- Tomas Glazer
- Rejlinde Vittka
- Zhan-Mari-Viktor De Vri
|
RU2154635C2 |
DERIVATIVES OF QUINOLINE-2-YL-METHOXYBENZYLHYDROXYUREA, METHOD OF SYNTHESIS AND 4-(QUINOLINE-2-YL-METHOXY)PHENYL-CYCLOALKYLKETONE AS A PARENTAL COMPOUND FOR SYNTHESIS OF QUINOLINE-2-YL-METHOXYBENZYLHYDROXYUREA DERIVATIVES |
1992 |
- Mikhael' Mattske[De]
- Klaus-Khel'Mut Mors[De]
- Zigfrid Raddats[De]
- Romanis Frukhtmann[De]
- Armin Khattsel'Mann[De]
- Kristian Kol'Sdorfer[De]
- Rajner Mjuller-Peddingkhauz[De]
- Pia Tajzen-Popp[De]
|
RU2048466C1 |
2,8-DISUBSTITUTED QUINAZOLINONE DERIVATIVES OR THEIR SALTS AND PHARMACEUTICAL COMPOSITIONS BASED ON THE LATTER AFFECTING BLOOD LEVELS OF GUANOSINE AND ADENOSINE MONOPHOSPHATES |
1996 |
- Fred Robert Khajker
- Ul'Rikh Nivener
- Vol'Fgang Khartvig
- Khel'Mut Shjutts
- Ehrvin Bishoff
- Ehlizabet Pertsborn
- Mattias Shramm
|
RU2158733C2 |
DERIVATIVES OF HALOGEN-SUBSTITUTED BENZIMIDAZOLE AND THEIR ACID-ADDITIVE SALTS, INTERMEDIATE COMPOUNDS AND FUNGICIDE AGENT |
1996 |
- Assmann Lutts
- Markhol'D Al'Brekht
- Timann Ral'F
- Shtentsel' Klaus
|
RU2170735C2 |
DIHYDROPYRIDINE DERIVATIVES, MIXTURE OF THEIR ISOMERS, INDIVIDUAL ISOMERS OR THEIR PHYSIOLOGICALLY TOLERANTABLE SALTS, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND METHOD OF THEIR SYNTHESIS |
1992 |
- Jurgen Shtol'Tefus[De]
- Zigfrid Gol'Dmann[De]
- Aleksander Shtraub[De]
- Khorst Beskhagen[De]
- Martin Bekhem[De]
- Rajner Gros[De]
- Zigbert Khebish[De]
- Joakhim Khjuttner[De]
- Khauard-Pol' Raunding[Gb]
|
RU2081872C1 |