FIELD: pharmaceutical chemistry. SUBSTANCE: phospholipid-free gangliosides that can be used as drugs are prepared by homogenization and acetone-assisted dehydration of gray matter followed by extraction with chloroform-acetone mixture and subsequent acetone (5:1)- mediated isolation of desired product, supernatant being preliminarily purified by acetone at ratio (1.5-2.0): 1 and filtered before isolation pf product. EFFECT: enabled removal of phospholipids without losses in specific biological activity of gangliosides. 4 ex
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Authors
Dates
2002-12-27—Published
2000-04-12—Filed