SUBSTITUTED BIARYL COMPOUNDS OR SUBSTITUTED PYRIDINES AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF Russian patent published in 2002 - IPC

FIELD: organic chemistry, medicine, endocrinology, pharmacy. SUBSTANCE: invention relates to biaryl compounds or substituted pyridines of the formula (I) where X means N or CR⁸ where R⁸ means hydrogen atom, halogen atom, phenyl, alkyl, alkoxy-group, alkoxycarbonyl, carboxy-group, formyl or -NR⁴R⁵ where R⁴ and R⁵ mean hydrogen atom, alkyl, alkenyl, cycloalkyl, phenyl, naphthyl; R^1a and R^1в mean trifluoromethyl, alkyl, alkenyl, alkynyl, cycloalkyl, alkanoyl; R² means alkyl, alkenyl, alkynyl, cycloalkyl; R³ means hydroxy-group, trifluoroacetyl, alkanoyl, alkenyl; Ar means aromatic or heteroaromatic ring, for example, phenyl, naphthyl, pyridyl, furanyl, thiophenyl. Compounds of the formula (I) show antagonistic effect with respect to glucagon receptor and can be used in treatment of glucagons-mediated states, for example, diabetes mellitus. EFFECT: valuable medicinal properties of compounds. 20 cl, 2 tbl