4-PHENYL-SUBSTITUTED TETRAHYDROISOQUINOLINES, PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT BASED ON THEREOF Russian patent published in 2007 - IPC C07D491/04 C07D495/04 C07D471/04 A61K31/4741 A61K31/4743 A61K31/4745 A61P25/00

Abstract RU 2301808 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel 4-phenyl-substituted tetrahydroisoquinolines of the formulae: (IA) , (IB) , (IIA) , (IIB) , (IIIA) and (IIIC) wherein values X and R¹-R⁷ are given in the invention description. Proposed compounds show selective binding of neurotransmitters and therefore they can be used in treatment of different neurological or psychological disorders, for example, ADHD. Also, invention relates to a pharmaceutical composition based on proposed compounds and to a method for treatment.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition, improved method of treatment.

36 cl, 1 dwg, 16 tbl, 131 ex

Similar patents RU2301808C2

Title	Year	Author	Number
DERIVATIVES OF TETRAHYDROISOQUINOLINE, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF, METHOD FOR INHIBITION OF SYNAPTIC UPTAKE OF DOPAMINE AND TREATMENT METHOD	2000	Bek Dzhejms P. Smit Mark A.	RU2293728C2
ACTIVATING AGENT FOR RECEPTOR ACTIVATED BY PEROXISOME GROWTH-STIMULATING AGENTS	2009	Sakuma Sogo Takakhasi Rie Nakamura Khideki	RU2501794C2
PESTICIDE COMPOSITIONS AND RELATED METHODS	2013	Lo Villyam K. Khanter Dzhejms E. Uotson Dzherald B. Patni Akshaj Ijer Pravin S. Boruva Dzhoshodip	RU2654327C2
CYCLIC N,N'-DIARYLTHIOUREAS OR N,N'-DIARYLUREAS - ANTAGONISTS OF ANDROGEN RECEPTORS, ANTI-CANCER MEDICATION, METHOD OF OBTAINING AND APPLICATION	2010	Ivashchenko Aleksandr Vasil'Evich Mit'Kin Oleg Dmitrievich	RU2434851C1
COMPOUNDS FOR TREATING CANCER	2010	Dolton Dzhejms T. Miller Duejn D. An Suntszo Chen Tszjantszun Djuk Charlz Li Chien-Min Li Vej Lu Jan Van Chzhao	RU2581367C2
1,2,4-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHBITORS	2007	Zhazherovik Nadin Kumela-Montanches Khose Marija Gojja-Lasa Marija Pilar Dordal Suehras Alberto Kuberes-Altisent Marija Rosa	RU2451015C2
DERIVATIVES OF PIPERIDINE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE COMPOUNDS	1997	Delorm Daniel' Roberts Ehdvard Vej Zhongjong	RU2193029C2
METHOD FOR SYNTHESIS OF BICYCLO[3,1,0]HEXANE DERIVATIVES AND INTERMEDIATE COMPOUND TO THIS END	2004	Khartner Frederik U. Tehn Lushi Jasuda Nobuesi Josikava Naoki	RU2388747C2
DERIVATIVES OF PYRROLOPYRIMIDINE, METHOD FOR PREPARING AND THEIR USING	2001	Kim Dae-Kee Li Dzu Jang Riu Do Khiun Li Nam Kiu Li Suk Kho Kim Nam-Kho Kim Dzae-Sun Riu Dze Kho Choj Dzin-Jang Im Guang-Dzin Choj Von-Son Kim Tae Kon Cha Khoon	RU2263676C2
DERIVATIVES OF TAXANE FUNCTIONED BY POSITION 14 AND METHOD FOR THEIR PREPARING	2003	Fontana Gabriele Bombardelli Ehtsio Battal'Ja Arturo Bal'Delli Ehleonora Gverrini Andrea Dzhel'Mi Marija Luiza Karentsi Dzhakomo Pokar Donato	RU2320652C2

RU 2 301 808 C2

Authors

Bek Dzhejms P.

Pechulis Ehntoni D.

Kharms Artur Eh.

Dates

2007-06-27—Published

2001-07-11—Filed