PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR δ ACTIVATING AGENT Russian patent published in 2011 - IPC C07D263/32 C07D277/22 C07D333/06 A61K31/421 A61K31/426 A61K31/381 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of general formula or pharmaceutically acceptable salt thereof, where each of W¹ and W² independently denotes CH; X denotes NR⁵ or CR⁶R⁷, where R⁵ is hydrogen, C_1-8alkyl, and each of R⁶ and R⁷ is independently hydrogen; Y denotes -(CR⁸R⁹)_n-, where each of R⁸ and R⁹ independently denotes hydrogen or C_1-8alkyl, and n is a number from 1 to 4; or X and Y together form -CR¹⁰=CR¹¹-, where each of R¹⁰ and R¹¹ independently denotes hydrogen; Z is carboxyl; G denotes O, S or CR¹²R¹³, where each of R¹² and R¹³ independently denotes hydrogen; A denotes a 5-member heterocyclic ring selected from a group consisting of thiazole, oxazole and thiophene, in which the heterocyclic ring is optionally substituted with C_1-8alkyl; B denotes a C_1-8alkylene or C_2-8alkenylene chain; each of R¹ and R² independently denotes hydrogen, C_1-8alkyl, halogen, C_1-8alkyl substituted with halogen, or hydroxyl; each of R³ and R⁴ independently denotes hydrogen or C_1-8alkyl; and m is equal to 0.

EFFECT: compounds of formula (I) act as peroxisome proliferator-activated receptor δ activators.

23 cl, 39 tbl, 14 ex