QUINAZOLINE SUBSTITUTED DERIVATIVES Russian patent published in 2002 - IPC

Abstract RU 2195456 C2

FIELD: organic chemistry, medicine, oncology. SUBSTANCE: invention relates to derivatives of quinazoline of the formula (I) where X means phenyl that can be optionally substituted with halogen atom; R, R1 and R2 mean hydrogen atom; Y means radical taken among group including groups of the formulas (a) , (b) , (c) , (d) , (e) , (f) ; R3 means independently hydrogen atom, alkyl with 1-6 carbon atoms, carboxy-, carboalkoxy-group with 1-6 carbon atoms or phenyl; n = 2-4; or their pharmaceutically acceptable salts under condition that each R3 in group Y can be similar of distinct. Compounds of the formula (I) inhibit effect of protein tyrosine kinases that are receptors of growth factors and can be used for treatment of cancer in mammals. Also, invention relates to methods of synthesis of indicated quinazolines, method of inhibition of biological effect of nonregulated protein tyrosine kinase activity in mammals, method of treatment and suppression of tumors growth in mammals and to pharmaceutical composition based on indicated compounds. EFFECT: valuable medicinal properties of compounds. 21 cl, 7 tbl

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RU 2 195 456 C2

Authors

Vissner Allan

Dzhonson Bernard Din

Flojd Middlton Broner Ml.

Kitchen Duglas Brjus

Dates

2002-12-27Published

1997-02-03Filed