FIELD: medicine, pharmacy. SUBSTANCE: invention relates to pharmaceutical composition comprising water-insoluble active compound 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl] -23,25- dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1. 04,9]-octacos-18-ene-2,3,10,16- tetraone, surface-active substance and solid carrier that promotes to enhancement of solubility and improvement of absorption of this composition in oral route of administration. EFFECT: improved properties of composition. 7 cl, 1 tbl, 1 dwg, 5 ex
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