PHARMACEUTICAL COMPOSITION SHOWING IMMUNOSUPPRESSIVE AND ANTIMICROBIAL ACTIVITIES Russian patent published in 1997 - IPC

FIELD: organic chemistry and technology. SUBSTANCE: product: compound of the formula (I) where: each adjacent pair R¹ and R², R³ and R⁴, or R⁵ and R⁶ means independently: (a) two adjacent hydrogen atoms, or (b) can form other bond with carbon atoms with that they were bound; R² - alkyl-group; R⁷ means hydrogen atom, hydroxyl group, protected hydroxyl group or alkoxyl group or forms together with R¹ hydroxy-group; R⁸ and R⁹ mean independently hydrogen atom or hydroxyl group; R¹⁰ means hydrogen atom, alkyl, group, alkyl group substituted with one or some hydroxyl groups, alkenyl group, alkenyl group substituted with one or some hydroxyl groups or alkyl group substituted with oxo-group; X¹ means hydrogen atom or hydroxyl group, or X² and X¹ can form together oxo-group or X²; -CH₂O- means hydrogen atom or hydroxyl group; Y¹ means hydrogen atom, or Y² and Y¹ can mean together oxo-group, N-Y² or N--NR¹¹R¹²; OR¹³ and R¹¹ are independently hydrogen atom, alkyl group, aryl group or tosyl group; each of R¹² and R¹³, R¹⁴, R¹⁵, R¹⁶, R¹⁷, R¹⁸, R¹⁹, R²² means independently hydrogen atom or alkyl group; R²³ and R²⁰ each means oxo-group or independently (R² and hydrogen atom) or (R20a

and hydrogen atom) where R21a and R20a each means independently hydroxyl group, alkoxyl group or group of the formula R21a, or -OCH₂OCH₂CH₂OCH₃ means protected hydroxyl group, or R21a and R20a can mean together oxygen atom in epoxy-ring; n - the whole number 1, 2 or 3; R21a together with carbon atoms to that they were bound can form saturated or unsaturated heterocyclic ring with 5 or 6 members containing nitrogen, sulfur and/or oxygen, or the indicated ring substituted with one or some groups taken from alkyl, hydroxy, alkyl substituted with one or some hydroxyl groups, alkoxy, benzyl and group of the formula Y¹, Y², R^10, R²³. Composition has compound of the formula (I) -CH₂Se(C₆H₅) or its pharmaceutically acceptable salt (particle size is 5 mcm, not above) and surface-active substance at the known their mass ratio. EFFECT: improved method of synthesis, enhanced effectiveness of composition. 7 cl, 2 tbl