INHIBITOR OF INTIMA HYPERTROPHY, USE OF HYDROXYINDOLE DERIVATIVE FOR SYNTHESIS OF INHIBITOR OF INTIMA HYPERTROPHY, COMPOSITIONS FOR INHIBITION OF INTIMA HYPERTROPHY, METHOD OF PROPHYLAXIS AND TREATMENT OF INTIMA HYPERTROPHY Russian patent published in 2000 - IPC

FIELD: medicine, organic chemistry. SUBSTANCE: invention relates to inhibitor of intima hypertrophy. Inhibitor has hydroxyindole derivative as an active component of the formula (I) or its salt where R′ means hydrogen atom, phenyl group that can be substituted with lower alkyl group, lower alkoxy-group, lower alkylaminoalkoxy-group, hydroxyl group, amino-group, lower alkylamino-group or halogen atom, or pyridyl group that can be substituted with lower alkyl group, lower alkoxy-group, lower alkylaminoalkoxy-group, hydroxyl group, amino-group, lower alkylamino-group, halogen atom, lower alkoxycarbonyl group or carboxyl group; phenyl group that can be substituted with, or pyridyl group that can be substituted with lower alkyl group, lower alkoxy-group, lower alkylaminoalkoxy-group, hydroxy-group, amino-group, lower alkylamino-group, halogen atom, lower alkoxycarbonyl-group or carboxyl group; hydrogen atom, lower alkyl group, benzyl group or benzenesulfonyl group that can be substituted or acyl group; hydrogen atom, lower alkoxy-group, halogen atom, amino-group, lower alkylamino-group, carboxyl group, lower alkoxycarbonyl group, phenylcarbamyl group that can be substituted, or trifluoromethyl group; CH-group or means the whole number from 0 to 4 that means a number of substituents and double dotted/ /unbroken line means a simple bond or a double bond. Agent shows the strong inhibitory effect directed against intima hypertrophy and used as an agent for prophylaxis/treatment/ /relaxation of proliferative vascular diseases as, for example, restenosis after PTCA, arteriosclerosis, peripheral embolia and angiitis. Invention relates to also the use of hydroxyindole derivative for synthesis of inhibitor of intima hypertrophy, composition for inhibition of intima hypertrophy and the method of prophylaxis and treatment of patients with intima hypertrophy. Described inhibitor is the effective agent used for prophylaxis of vessel restenosis after angioplasty and for treatment of patients with arteriosclerosis. EFFECT: enhanced effectiveness of inhibitor described above. 9 cl, 2 dwg, 24 tbl, 18 ex