FIELD: organic chemistry. SUBSTANCE: invention relates to pharmaceutical composition as emulsion or solution that shows IMMUNOSUPPRESSIVE effect and has compound of the formula (I) 
as an active component that is given in description text. Composition has the special additions - emulsifier and lipophilic agent. Emulsifier - substance taken from the group involving egg yolk lecithin, soybean lecithin, products of their hydrogenization, phosphatitylcholine, phosphatidylserine, gum arabic, gelatin, castor oil hardened with polyhydroxyethylene, ester of polyhydroxyethylenesorbitane and fatty acid, ester of polyhydroxyethylene and fatty acid, mono- and diglycerides of fatty acids with the mean chain length and polyhydroxyethylated glyceride. Lipophilic agent is taken from the group: soybean, sesame, cotton, safflower, corn, rape, peanut oils, fatty acid triglycerides with the mean chain length and liquid hydrocarbons. Content of compound (I) is 0.05-50 mg/ml, lipophilic agent - 5-20 wt.-%, mass ratio of emulsifier : lipophilic agent = 0.5-400:100. Composition can contain additionally organic solvent at amount 0.002-2 ml, preferably, 0.01-1 ml, or 0.02-0.5 ml/1 mg compound (I) and can present the solution. Composition can be prepared as emulsion "oil-in-water" and has water additionally. Composition is prepared by components mixing. Composition can be used in medicine at organ transplantation. EFFECT: improved method of synthesis. 11 cl, 2 tbl
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RU2119922C1 |
