DERIVATIVES OF ADAMANTANE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHOD OF ITS PREPARING AND METHOD OF EFFECT ON IMMUNE SUPPRESSION Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to novel compounds of the formula (I) where A means group CH₂ or oxygen atom; B means hydrogen or halogen atom; D means CH₂, OCH₂, NHCH₂, CH₂CH₂; R means phenyl, benzothiazolyl, indolyl, indazolyl, purinyl, pyridyl, pyrimidinyl, thiophenyl being each of these groups can be substituted or unsubstituted. Invention relates also to method of synthesis of these compounds that involves interaction of compound of the formula (II) where L means a removable group with compound of the formula . These compounds show antagonistic activity with respect to P2X7 receptor and owing to this property they can be used as active component in pharmaceutical composition and in method of effect on immune suppression. EFFECT: improved methods of synthesis and preparing, valuable medicinal property of compounds. 11 cl