DERIVATIVES OF ADAMANTANE, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION AND METHOD FOR PREPARING PHARMACEUTICAL COMPOSITION Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention describes derivatives of adamantine of the general formula (I): wherein x = 1 or 2; A represents group CH₂; B represents hydrogen or halogen atom; R represents phenyl, pyridyl or indolyl group being each of that can be substituted with halogen atom, amino-group, nitro-group, C₁-C₆-alkyl, 3-8-membered heterocyclyl, C₁-C₆-alkylsulfinic group, C₁-C₆-alkoxy-group, C₁-C₆-alkylamine, benzyl, C₁-C₆-alkylthio-group, phenylthio-group and others. Invention relates also to method for preparing compound of the formula (I). Invention represents pharmaceutical composition eliciting antagonistic activity with respect to receptors P2X₇ and method for its preparing. Invention provides development of compounds showing effectiveness as antagonists of receptor P2X₇ for their using in treatment of inflammatory, immune and cardiovascular diseases. EFFECT: improved preparing method, valuable medicinal properties of compounds. 9 cl, 82 ex