DERIVATIVES OF BIPHENYLAMIDINE Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to derivatives of biphenyl-amidine of the general formula (1) where R¹ means hydrogen atom; L means a single bond or C_1-4-alkylene group; R² means carboxyl group, C_1-8- alkoxycarbonyl group, carbamoyl group being nitrogen atom of carbamoyl group can be substituted with mono- or di-C_1-8-alkyl group or can mean nitrogen atom in amino acid, C_1-8-alkylcarbonyl group; R³ means hydrogen atom; X means any group among the following ones: -O-, -NH-CO-NH-, where R⁴ means hydrogen atom, C_1-10-alkyl group, C_1-10-alkylcarbonyl group, C_1-10-alkylsulfonyl group; R⁵ means hydrogen atom, C_1-10-alkyl group; Y means C_4-8-cycloalkyl group where methylene group in C_4-8-cycloalkyl can be substituted with C_1-8-alkyl group, C_1-8-alkoxyl group, carbamoyl group, C_1-8-alkoxycarbonyl group, carboxyl group or the following 5-8-membered ring of the formula (I-1) . These compounds show inhibitory activity of blood coagulation activated X-factor and owing to this property they can be used as agents for prophylaxis or therapy of thrombosis or embolism. EFFECT: valuable medicinal properties of compounds. 9 cl, 4 tbl