ACYLATED HETEROALICYCLIC DERIVATIVES, MEDICINAL AGENT SHOWING SELECTIVE ANTAGONISTIC ACTIVITY AGAINST NK-RECEPTORS, METHOD OF PROPHYLAXIS OR TREATMENT OF PATIENTS Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel compounds of the formula (I) where R¹ means (C₃-C₇)-cyclo-alkyl group or 3-7-membered saturated heterocyclic group with 1 or 2 heteroatoms taken among nitrogen, oxygen or sulfur that can be optionally substituted with oxo-group; R² means aryl group that can be optionally substituted with 1-3 halogen atoms; A means methylene or carbonyl group; B means a simple bond; D means oxygen or sulfur atom; G means (C₁-C₄)-alkylene group; L means the group of the formula -C(R⁴)(R⁵)- where R⁴,R⁵ are given in the invention claim; Z means two hydrogen atoms or oxygen atom; n = 0 or 1 and to its pharmaceutically acceptable salts, esters, quaternary amines or hydrates. Also, invention relates to medicinal agent based on indicated compounds that shows selective antagonistic activity against NK₂-receptors and method of prophylaxis or treatment of patients. Invention can be used in medicine for treatment of patients with central nervous system diseases. EFFECT: new compounds indicated above, valuable medicinal properties. 20 cl, 2 tbl, 13 ex