FIELD: chemistry.
SUBSTANCE: invention relates to a compound represented by the formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 means OR, NRR', which can form a ring, or SR. Wherein R and R' independently mean hydrogen atom, linear, cyclic or branched alkyl containing 1-8 carbon atoms, and optionally substituted by one or more linear, circular, or branched alkoxygroup containing 1-8 carbon atoms, halogen atoms or hydroxyl groups, monocyclic or bicyclic aryl containing 6-10 carbon atoms, optionally substituted by one or more linear, cyclic or branched alkyl containing 1-8 carbon atoms, linear, cyclic or branched alkoxygroup containing 1-8 carbon atoms, or halogen atoms, where the term "NRR' forms a ring" means that R and R' join to form pyrrolidine-1-yl group; R2 means a hydrogen atom or a linear, cyclic or branched alkyl containing 1-8 carbon atoms; X1, X2 and X3 mean independently CR3 or a nitrogen atom, or X1 means CR3 or a nitrogen atom, and X2 and X3 together form a benzene ring. Moreover, R3 means a hydrogen atom or a linear, cyclic or branched alkyl having 1-8 carbon atoms. The invention also relates to specific compounds corresponding to formula (I). The invention relates to an intermediate compounds represented by the formulas,
and
, where R1, R2, X1, X2 and X3 correspond to the values given for compounds of formula (I) and R4 means protective group of the carboxylic group, selected from methyl, ethyl, isopropyl, heptyl, tert-butyl, methoxymethyl, methylthiomethyl, methoxyethoxymethyl, propanol and benzyl, and R5 means a protective group of phenolic hydroxyl group selected from methyl, isopropyl, allyl, tert-butyl, methoxymethyl, methylthiomethyl, methoxyethoxymethyl, 1-ethoxyethyl, benzyl, 4-methoxybenzyl, acetyl, trimethylsilyl, t-butyldimethylsilyl. The compounds of the invention of formula (I) have an inhibitory activity against xanthine oxidase.
EFFECT: azole derivatives of benzene as inhibitors of xanthine oxidase.
19 cl, 15 tbl, 58 ex
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Authors
Dates
2018-01-23—Published
2014-01-30—Filed