DERIVATIVES OF PIPERAZINE Russian patent published in 2003 - IPC

FIELD: organic chemistry, heterocyclic compounds, medicine, pharmacy. SUBSTANCE: invention relates to derivatives of piperazine of the formula (a) where A means heterocyclic group with 5-6 atoms in ring where 1-2 heteroatoms among group O and N; R₁ mean hydrogen; R₂ means C_1-4-alkyl, C_1-4-alkoxy-group or oxo-group; p = 0, 1 or 2; Z means nitrogen atom and dotted line means a single bond; R₂ and R₄ mean hydrogen atom; n = 1; R₅ means 2-pyridyl, 3-pyridyl or 4- pyridyl. Compounds can be used for treatment of patients suffering with schizophrenia and other psychotic disorders. Invention describes also intermediate compounds used in synthesis of compounds proposed. EFFECT: valuable medicinal properties of compounds. 5 cl, 9 sch, 2 tbl, 3 ex