DERIVATIVES OF PIPERAZINE AND PIPERIDINE AND METHOD OF THEIR SYNTHESIS Russian patent published in 2002 - IPC

FIELD: organic chemistry, heterocyclic compound. SUBSTANCE: invention relates to derivatives of piperazine and piperidine of the general formula (a) where A means heterocyclic group with 5-7 atoms in ring containing 1-2 heteroatoms among O, N and S atoms; R₁ means hydrogen or fluorine atom; R₂ means oxo-group or C_1-4-alkyl and p = 0 or 1; Z means carbon or nitrogen atom and dotted line means a simple bond when Z means nitrogen atom and simple or double bond when Z means carbon atom; R₃ and R₄ mean independently each of other hydrogen atom or C_1-4-alkyl; n = 1 or 2; R₅ means C_1-4-alkoxy-group, C_1-4-alkyl, halogen atom or hydroxy-group and q = 0 or 1; Y means phenyl substituted with 1-2 substitutes taken among hydroxy-group, halogen atom, C_1-4-alkoxy-group, cyano-group, aminocarbonyl-group, di-C_1-4-alkylaminocarbonyl-group, furyl or thienyl and their salts. Invention describes also method of synthesis of these compound. The claimed compounds show high degree of affinity to both dopamine D₂-receptors and serotonin 5-HT_1A receptors. EFFECT: improved method of synthesis, valuable pharmacological properties. 6 cl, 6 tbl