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2 349 591

(13)

(51)

IPC

C07D471/04(2006-01-01)

A61K31/4985(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2006114051/04, 2004-09-23

(24)

Start date

2004-09-23

(22)

Actual filing date

2004-09-23

(45)

Published

2009-03-20

(72)

Inventor

Ivema Bakker Vauter I.Van Skharrenburg Gjustaf J. M.Van Den Khogenband AndrianusMakkriri Ehndrju S.

(73)

Holder

Solvej Farmas'Jutikals B.V.

HEXA- AND OCTAHYDROPYRIDO[1,2-a]PYRAZINE DERIVATIVES WITH NK-ANTAGONIST ACTIVITY Russian patent published in 2009 - IPC C07D471/04 A61K31/4985 A61P25/00

Abstract RU 2349591 C2

FIELD: chemistry.

SUBSTANCE: present invention pertains to hexahydropyrido[1,2-a]pyrazine derivatives. The invention also relates to methods of producing these compounds, to pharmaceutical compositions, containing a pharmacologically active amount of at least, one of these compounds as an active ingredient, as well as to use of these compositions for treating disorders, involving neurokinin receptors. The invention also relates to compounds with general formula (1) in which the denotations of symbols are given in the description.

EFFECT: exhibition of antagonistic activity towards neurokinin receptor NK_1.

6 cl, 13 ex, 1 dwg

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RU 2 349 591 C2

Authors

Ivema Bakker Vauter I.

Van Skharrenburg Gjustaf J. M.

Van Den Khogenband Andrianus

Makkriri Ehndrju S.

Dates

2009-03-20—Published

2004-09-23—Filed