PHENYLGLYCINE DERIVATIVES Russian patent published in 2003 - IPC

FIELD: organic chemistry, amino acids. SUBSTANCE: invention relates to novel compounds of the formula (I) where R¹ means hydrogen atom or fragment of ester; E means hydrogen atom or hydroxy-group; X¹-X⁴ mean group C(R^a),C(R^b) or C(R^c) and fourth means C(R^d) or N where R^a-R^d mean hydrogen atom, alkenyl, alkynyl, alkenyloxy, alkoxy, alkylamino, alkoxyalkoxy, alkoxyalkyl-aminoalkyl, alkoxycarbonylalkyl, alkoxycarbonylarylalkoxy, alkoxy-carbonylalkylcarboxamido, alkyl, alkoxycarbonylcarboxamido, alkyl-sulfanyl, alkylsulfinyl, alkylsulfonyl, alkylureido, alkylthioureido, alkylsulfonylaminoalkoxy, alkylsulfonylamino, aminoalkoxy, arylalkenyl, arylalkoxy, arylalkyl, arylalkylcarboxamido, arylcarbonyl-alkoxy, Arylcarboxamido, aryloxy, aryloxyalkoxy, arylsulfonylamino, arylsulfonylaminoalkoxy, carboxy, carboxyalkyl, substituted alkyl, substituted amino, halogen atom, substituted halogen atom, cycloalkyl, substituted cycloalkyl, hydroxy-group, substituted hydroxy-group, heterocycle, substituted heterocycle; or two adjacent groups from R^a-R^d form in common fragment of condensed di- or mono-oxane ring or aryl ring. Indicated compounds exhibit amidolytic activity with respect to complex factor VIIa/tissue factor and owing to this property they can be used as active component in pharmaceutical composition and for treatment of different diseases caused by this activity. EFFECT: valuable biochemical activity and properties. 24 cl, 362 ex