CARBOXAMIDES, THEIR HYDRATES AND SOLVATES AND PHYSIOLOGICALLY COMPATIBLE SALTS Russian patent published in 1999 - IPC

FIELD: organic synthesis. SUBSTANCE: invention provides new carboxamides with general formula I: (I) wherein E is hydrogen; G hydrogen, lower alkyl, lower alkylenecarboxy, lower alkoxycarbonyl, lower alkanoyl, lower alkanoyloxy, lower alkoxy, aryl- lower alkoxy, carboxamide group, etc.; M is hydrogen, lower alkyl, lower alkenyl, aryl, heteroaryl, or cycloalkyl; L hydrogen, lower alkyl, aryl, or cycloalkyl; or M and L together with atoms adjacent to them represent heterocyclic nitrogen atom; or E and G together form methylene or carbonyl group; A is hydrogen, alkyl, or arylalkyl; Q is group of formula or wherein T is methylene or oxygen, and R⁶ and R⁷ are hydrogen, lower alkoxycarbonyl, or hydroxyl. EFFECT: new means to inhibit thrombin-induced accumulation of platelets and coagulation of fibrinogen in blood serum. 18 cl, 1 tbl, 53 ex