METHOD OF SYNTHESIS OF CARBOXYLIC OR SULFONIC ACID AMIDES OR THEIR PHYSIOLOGICALLY COMPATIBLE SALTS Russian patent published in 1997 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: product: carboxylic or sulfonic acid amides of the formula R′-A-(W)_a-X-(CH₂)_b-(Y)_c-B-Z-COOR, where: A - ; B - C₆H₃-R⁴ or ; W - CH₂,CH₂CH₂,(CH₂)₃, CH=CH; X - CONR²,NR²CO,SO₂NR²; Y - CH₂CH₂O,OCH₂, CH=CH, ; Z - OCH₂,NR⁶CH₂,CH₂,, CH=CH, (CH₂)₂,C(CH₃)=CH,CH(CH₃)CH₂; R - H, lower alkyl; R¹ - amidino; R² - H, lower alkyl, lower alkoxy, halogen, lower carbalkoxy; Q¹ and Q² - H, lower alkyl; R⁴ - H, lower alkyl, lower carbalkoxy, lower alkoxy, halogen, CH=CHCH₂CH₂COO (H or benzyl), ZCOOR; R⁶ - H, benzyl; c = 0, 1; b = 0-2 being a and b = 0 if c = 1 and c = 0 if a and b are distinct from 0. Reagent 1: NC-A-(W)_a-X-(CH₂)_b-(Y)-B-Z-COOR that is converted to amidine with the following compound isolation of the defined composition or its conversion to the physiologically compatible salt. EFFECT: improved method of synthesis.