POLYPEPTIDES COMPRISING A SINGLE COVALENTLY BOUND N-TERMINAL WATER-SOLUBLE POLYMER Russian patent published in 2003 - IPC

Abstract RU 2199347 C2

FIELD: chemistry of proteins, pharmacy. SUBSTANCE: invention relates to compositions consisting of polypeptide and water-soluble polymer that is bound covalently with polypeptide by N-terminal α-carbon atom through hydrazone or reduced hydrazone bond. Invention relates also to methods of preparing compositions of this invention, pharmaceutical compositions including thereof and sets for their preparing. Invention allows to carry out complex procedures in preparing covalently bound polypeptides with improved precision and simplicity. EFFECT: improved method of preparing. 12 cl, 7 dwg, 4 ex

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RU 2 199 347 C2

Authors

Vej Ziping

Menon-Rudol'F Sanita

Gosh-Dastidar Pradip

Dates

2003-02-27—Published

1997-08-01—Filed